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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC1
All Species:
51.82
Human Site:
S236
Identified Species:
76
UniProt:
Q13547
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13547
NP_004955.2
482
55103
S236
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Chimpanzee
Pan troglodytes
XP_519834
482
55098
S236
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Rhesus Macaque
Macaca mulatta
XP_001096929
485
54378
S245
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Dog
Lupus familis
XP_544435
482
55144
S236
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Cat
Felis silvestris
Mouse
Mus musculus
O09106
482
55056
S236
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Rat
Rattus norvegicus
Q4QQW4
482
55074
S236
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
S233
R
D
G
I
D
D
E
S
Y
G
Q
I
F
K
P
Chicken
Gallus gallus
P56517
480
54920
S236
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Frog
Xenopus laevis
O42227
480
54874
S236
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
G210
T
G
D
M
Y
E
V
G
A
E
S
G
R
Y
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
A234
R
D
G
M
D
D
D
A
Y
E
S
I
F
V
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
S240
R
D
G
I
T
D
V
S
Y
Q
S
I
F
K
P
Sea Urchin
Strong. purpuratus
P56518
576
64060
S235
R
D
G
I
D
D
E
S
Y
D
K
I
F
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
S249
D
D
G
I
D
D
E
S
Y
Q
S
L
F
K
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22446
501
56004
S244
D
D
G
I
D
D
E
S
Y
H
L
L
F
K
P
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
G217
K
Y
G
E
F
F
P
G
T
G
E
L
R
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
88.4
99.1
N.A.
99.3
99.1
N.A.
83.4
93.3
91
54.3
N.A.
71.9
N.A.
59.5
69.6
Protein Similarity:
100
100
90.7
99.5
N.A.
100
100
N.A.
89
96.4
96.8
71.3
N.A.
82.1
N.A.
77.5
77.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
86.6
100
100
6.6
N.A.
66.6
N.A.
73.3
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
100
100
26.6
N.A.
93.3
N.A.
86.6
93.3
Percent
Protein Identity:
N.A.
53.2
N.A.
56.6
54.5
N.A.
Protein Similarity:
N.A.
69.9
N.A.
71
70.1
N.A.
P-Site Identity:
N.A.
73.3
N.A.
73.3
6.6
N.A.
P-Site Similarity:
N.A.
93.3
N.A.
80
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
7
0
50
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
13
88
7
0
82
88
7
0
0
7
0
0
0
7
0
% D
% Glu:
0
0
0
7
0
7
75
0
0
63
7
0
0
0
0
% E
% Phe:
0
0
0
0
7
7
0
0
0
0
0
0
88
0
0
% F
% Gly:
0
7
94
0
0
0
0
13
0
13
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
82
0
0
0
0
0
0
0
75
0
0
7
% I
% Lys:
7
0
0
0
0
0
0
0
0
0
7
0
0
82
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
7
19
0
0
0
% L
% Met:
0
0
0
13
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
88
% P
% Gln:
0
0
0
0
0
0
0
0
0
13
7
0
0
0
0
% Q
% Arg:
75
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% R
% Ser:
0
0
0
0
0
0
0
82
0
0
25
0
0
0
0
% S
% Thr:
7
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
13
0
0
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
7
0
0
0
88
0
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _